The most common full form of LPS is Lipopolysaccharide, also known as Polysaccharides. It refers to a molecule found in the outer layer or membrane of the Gram-negative bacteria and is considered one of the most important parts. Interestingly, LPS can cause inflammation, sepsis, and fever in humans and animals. Additionally, it is also suspected in other common diseases such as atherosclerosis, Alzheimer’s, and rheumatoid arthritis.
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Components of LPS
Table of Contents
LPS is a complex protein that consists of three major components including lipid A, oligosaccharide, and O antigen. Here is what you need to know about them:
- The innermost portion of LPS is called Lipid A. It is embedded in the bacterial membrane and is composed of fatty acid chains and phosphorylated glucosamine.
- The core oligosaccharide refers to a carbohydrate chain. It connects lipid A to the antigen O.
- The O antigen refers to the outermost part of the LPS. It is a chain of sugar molecules, responsible for antigenic diversity.
Features of Lipopolysaccharide
LPS is known for its strong immune response in the host and endotoxin activity. When released from bacterial cells, it can lead to fever, inflammation, and cytokines. Let us know about some of the features of LPS
- The difference of 0 antigen in LPS causes differences in antigenic characteristics. Such differences are essential for scientists to identify and classify bacteria.
- LPS is known for playing an essential role in maintaining the structural stability of the bacterial cell.
- It also plays a significant role in the barrier function of the bacterial outer membrane and regulates the passage of nutrients, ions, and molecules.
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